The effects of 12-lipoxygenase metabolites on vascular permeability in the rat skin by Mei Mei Wang

Cover of: The effects of 12-lipoxygenase metabolites on vascular permeability in the rat skin | Mei Mei Wang

Published by National Library of Canada = Bibliothèque nationale du Canada in Ottawa .

Written in English

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SeriesCanadian theses = Thèses canadiennes
The Physical Object
Pagination1 microfiche.
ID Numbers
Open LibraryOL18791416M
ISBN 100612288064

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Pulp was experimentally inflamed by applying bacterial lipopolysaccharide (LPS). Changes in arachidonic acid (AA) metabolites were determined by measu Cited by: ALOX15 (also termed arachidonate lipoxygenase, lipoxygenase-1, LO-1, LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products.

Gene Function. Kelavkar and Badr () stated that the ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and Aliases: ALOX15, LOX, LOX-1, 15LOX-1.

Comparative effect of lipoxygenase products of arachidonic acid on rat aortic smooth muscle cell migration. Nakao J, Ooyama T, Ito H, Chang WC, Murota S. We investigated the effects of mono-hydroxyeicosatetraenoic acids (HETEs) and N-formyl-methionyl-leucyl-phenylalanine (F-Met-Leu-Phe) on rat aortic smooth muscle cell migration in modified Cited by: Bradykinin has been shown to be an important mediator of pain and irritation in skin, muscle, joints, vasculature, and all visceral organs.

87,97,– Bradykinin excites 55% of skin C-fibers in rat, 71% of joint afferents in cat, and % of cardiac afferents in cat. Almost % of guinea pig airway vagal afferents responded to.

A book of the names and address of people living in a city The soldiers of which nation committed the Mei Li 'The effects of lipoxygenase metabolites on vascular permeability in the rat. Previous studies suggest either an anti- or pro-apoptotic role for lipoxygenase-1 in carcinogenesis.

We used adenovirus gene transfer of human lipoxygenase-1 to characterize its effects in. Eicosanoid regulation of angiogenesis: Role of endothelial arachidonate lipoxygenase Article (PDF Available) in Blood 95(7) May with Reads How we measure 'reads'.

The cited metabolites may use one or the other of these two mechanisms in different vascular beds and in different animal species to contribute in regulating regional blood flow and blood pressure. While the role of these metabolites in the human vasculature has not been studied, 12 S -HETE, 12 R -HETE, HxA3, TrXA3, and TrXC3 do inhibit the CAS Number: 14 C-Arachidonic Acid Metabolism.

In order to identify the arachidonic acid metabolites produced by female and male pulmonary arteries, segments of intrapulmonary artery (70 mg of wet weight) were incubated in HEPES buffer (in mmol/L: HE NaClKCl 5, CaCl 2 2, MgCl 2 1, and glucose 6, pH ) containing 14 C-arachidonic acid ( μCi, 10 −7 mol/L) and the calcium ionophore Cited by: The most effective and safe treatment site for pain is in the skin.

This chapter discusses the reasons to treat pain in the skin. Pain is sensed in the skin through transient receptor potential cation channels and other receptors. These receptors have endogenous agonists (yang) and antagonists (yin) that help the body control pain.

Acupuncture works through modulation of these receptor Cited by: 4. Retinopathy of prematurity (ROP) is a common retinal disease in preterm babies. To prolong the lives of preterm babies, high oxygen is provided to mimic the oxygen level in the intrauterine environment for postnatal organ development.

However, hyperoxia-hypoxia induced pathological events occur when babies return to room air, leading to ROP with neuronal degeneration and vascular abnormality Cited by: 1. Ruzicka T, Walter JF, Printz MP (b) Changes in arachidonic acid metabolism in ultraviolet-irradiated hairless mouse skin.

J Invest Dermatol – Google Scholar Ruzicka T, Wasserman SI, Soter NA, Printz MP (c) Inhibition of rat mast cell arachidonic acid cyclooxygenase by by:   The Physiology and Pathophysiology of Lipoxygenases in the Skin. Authors; Authors and affiliations Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure.

() Role of ‘platelet-type’ lipoxygenase in skin carcinogenesis. Cancer Lett – Author: Peter Krieg, Gerhard Fürstenberger. Disturbances of Lipid Peroxidation in Rat Liver Cancer Cells and in Normal Regenerating Rat Liver. Pages Epidermal Growth Factor Enhances a Microsomal 12 — Lipoxygenase Activity in A Cells.

Pages Disorders of Vascular Permeability: Pathophysiological and. Their metabolites are lipid peroxides that can react with other biological compounds and alter the cellular redox state.

Many of the physiological roles of lipoxygenases are still unknown, but 5-lipoxygenase is involved in leukotriene metabolism, lipoxygenase in the angiotensin pathway, and lipoxygenase in reticulocyte maturation/5.

A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to glycyrrhetic acid, which inhibits 11 beta-hydroxysteroid dehydrogenase and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium.

Effects of Crocus sativus petals’ extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum.

Ethnopharmacol. 84, With rat liver microsomes, considerable information can be obtained from comparisons of gender effects and treatments of the rats with various inducers. For instance, very high inducibility with phenobarbital would ®rst suggest CYP2B1 or 2B2; a male-speci®c activity that is attenuated in rats treated with polycyclic hydrocarbons would suggest.

This article aims to provide detailed information on Malaysian plants used for treating inflammation. An extensive search on electronic databases including PubMed, Google Scholar, Scopus, and ScienceDirect and conference papers was done to find relevant articles on anti-inflammatory activity of Malaysian medicinal plants.

The keyword search terms used were inflammation, Cited by: 2. This banner text can have markup. web; books; video; audio; software; images; Toggle navigation. [] H. Maeda, Y. Noguchi, K. Sato, and T. Akaike, "Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor," Japanese Journal of Cancer Research, vol.

85, no. 4, pp.You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read.

Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism The leukotrienes generally have powerful effects on vascular permeability and the leukotriene LTB 4 is a potent chemoattractant for leukocytes and Various biological activities have been reported for the lipoxygenase metabolites of.

37 Poeckel D, Tausch L, Kather N, Jauch J, Werz O. Boswellic acids stimulate arachidonic acid release and lipoxygenase activity in human platelets independent of Ca 2+ and differentially interact with platelet-type lipoxygenase.

Mol Pharmacol ; Cited by: Effects of Bixa orellana leaves extract on increased paw volume and peritoneal vascular permeability induced by 5-HT in rats Armatu, A.

Determination of antioxidant and radical scavenging activity of Inula helenium L. roots. The listed Nobel prizewinners in biochemistry and molecular biology have been omitted except for eponymous entries, when they have lent their names to compounds or procedures.

There has been a judicious removal of some older terms, though we found that surprisingly few have disappeared from the literature to such an extent that they are obsolete.

The Fifth Congress was developed around themes relating to ocular drug metabolism, the ocular pathophysiological effects of nitric oxide, government issues relating to the use of alternative methods for toxicity testing, and a workshop that encompassed comparisons of both in vitro versus in vivo models as well as different animal models.

In addition to inhibition of the endocrine secretions, somatostatin has direct effects on a number of target organs (9). For example, it is a potent inhibitor of basal and prostaglandin-stimulated gastric acid secretion.

It also has marked effects on GI transit time, intestinal motility, and absorption of nutrients from the small intestine. The present invention provides methods and compositions for improving the effectiveness of suboptimally administered drug therapy and / or for reducing side effects.

The present invention relates to methods and compositions for improving the therapeutic effects of previously limited therapeutic agents by suboptimal therapeutic action. The improvement is done by improving the utility of a Author: デニス エム ブラウン. Extra dietary choline may be advantageous during pregnancy and lactation in rats." Prenatal choline may improve memory in offspring rats.

(Zeisel et al, ) Zeisel, S. H., Mr, M. H., Zhou, Z. and Da Costa, K. Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. pulmonary vascular diseases, and a 1,page Textbook of Pulmonary Vascular Disease.[4] This trio of publications illustrate the crucial point that many of Medicine’s most important.

The extensive diversity of membrane lipids is rarely appreciated by cell and molecular biologists. Although most researchers are familiar with the three main classes of lipids inCited by: Chromatop., () Windler, E.

and Havel, R.J.: Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver.

FIGURE Hemophilic arthropathy. The chronic effects of a repeated hemorrhage into the knee of a severely affected hemophilic. FIGURE Various radiologic stages of hemophilic arthropathy. The stages 0 (normal joint) and 1 (fluid in the joint) are not shown.

A: Stage 2 shows some osteoporosis and epiphyseal overgrowth in knee 2. Abubakar, M G, Taylor, A and Ferns, G A () The Effects of Aluminium and Selenium Supplementation on Brain and Liver Antioxidant Status in the Rat African Journal of Biotechnology, 3 (1).

Acuna-Rivera, M () Sustainable Development. effects on copper bioavailability because they concern how much metal is taken up relative to the total amount of metal in the exposure water; however, the effects of calcium on gill permeability might also simply make it more or less difficult for a fish to osmoregulate and thus change its susceptibility to copper without altering copper.

Weinheim: Wiley- VCH. 5 Schmidt V1, McEwan N, Volk A, Helps J, Morrell K, Nuttall T. The glucocorticoid sparing efficacy of Phytopica in the management of canine atopic dermatitis. Vet Dermatol. Feb;21(1) 6 Yang Y, Zhang Z, Li S, Ye X, Li X, He K. Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis.

Lung Cellular and Molecular Physiology) Hypoxia Inhibits Adenylyl Cyclase Catalytic Activity in a Porcine Model of Persistent Pulmonary Hypertension of the Newborn.

Authors: Yin J, Lv L, Zhai P, Long T, Zhou Q, Pan H, Botwe G, Wang L, Wang Q, Tan L, Kuebler WM Abstract Increased pulmonary vascular permeability is a hallmark of acute lung injury. Transient receptor potential subfamily V, member 1 (TRPV1) channels are important integrators of noxious stimuli with pronounced expression in nociceptive neurons.

Local anesthetics have been shown to modulate these nonselective cation channels in vivo and in vitro. However, little is known about the specific interactions between local anesthetic molecules and TRPV1 channels.

This thesis. Effects of phospholipase A2, lipoxygenase, and cyclooxygenase inhibitors in the feline pulmonary bed. (Kaye AD, Neonatal hypoxic hyperlipidemia in the rat: effects on aldosterone and corticosterone synthesis in vitro.

Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone. Effects Of Aqueous Extracts Of Zanthoxylum Macrophylla Roots On Membrane Stability Of Human In vitro induction of rat liver mitochondrial membrane permeability transition pore opening by solvent extracts of Expression of cyclooxygenase-2 and lipoxygenase in human breast cancer and their relationship with HER-2/neu.The eld of reactive oxygen metabolites ROM is full of these dualities.

Throughout the book the author points out the pros and cons of superoxide radical anion, superoxide dismutase, metal ions, ascorbic acid (antioxidant and prooxidant), a-tocopherol (antioxidant and prooxidant), and many other examples.Detre A, et. al., Studies on Vascular Permeability in Hypertension: Action of Anthocyanosides.

via the inhibition of the 12 lipoxygenase enzyme system, is attracting a great deal of attention.

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